Sofosbuvir Powder CAS 1190307-88-0
CAS NO.:1190307-88-0
Molecular Formula:C22H29FN3O9P
Purity & Grade: 99% HPLC; Medicine grade
MOQ & Package: 10g; Package according to demand
Store & Shelf life: Cool & dry place; 24 months
Lead Time: 1-3 days
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विवरण
is a white solid that is soluble in DMSO (a little) and methanol (a little). This substance is a prodrug that can be metabolized into the active antiviral drug 2'-deoxy-2'- -fluoro- -C-methyluridine-5'-monophosphate, which is currently in Phase 3 clinical trials for the treatment of hepatitis C. Studies have shown that sofosbuvir is a nucleotide inhibitor of hepatitis C virus and has a selective inhibitory effect on HCV NS5B polymerase.
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is a nucleotide prodrug targeting NS5B. It is first converted into the active drug ingredient, uridine triphosphate analog (GS-461203) in the liver, and then inhibits RNA-dependent RNA polymerase activity by binding to uridine nucleoside, and hinders the synthesis of HCV RNA by acting as a "chain terminator". NS5B polymerase is a key enzyme required for the HCV virus to synthesize double-stranded RNA from single-stranded RNA. It has three domains [thumb, fingers, and palm] and multiple allosteric sites (Thumb I, Thumb II, Palm, etc.), among which the active center is located in the palm region.
A smooth, exceptionally sensitive, correct, and extra reproducible RP-HPLC technique was developed and demonstrated to estimate Sofosbuvir (SOF) in pharmaceutical dosage formulations. This process was carried out by Agilent High-Pressure Liquid Chromatograph 1260 with GI311C Quat. Pump, Phenomenex Luna C-18 (150 mm × 4.6 mm × 5 μm) (USA), and Photodiode Array Detector (PDA) G1315D. The cell section, including acetonitrile and methanol with 80:20 v/v and solution (B) 0.1% phosphoric acid (40:60), was used for the study.
However, 10 μL of the sample was injected with a drift flow of 1 mL/min. The separation occurred at a column temperature of 30 degree , and the eluents used PDA set at 26{{10}} nm. The retention time of SOF was 5 min. The calibration curve was modified linearly within the range of 0.05-0.15 mg/mL with a correlation coefficient of 0.99 and genuine linear dating among top vicinity and consciousness in the calibration curve. The detection and quantification restrictions were 0.001 and 0.003 mg/mL, respectively. SOF recovery from pharmaceutical components ranged from 98% to 99%.
| White or Off-White Powder | ||
| No more than 1.0% | 0.003 | |
| No more than 0.1% | ||
| No more than 20ppm | ||
| Total impurities no more than 1.5% | 0.40% | |
| No less than 98.5% | 0.996 | |
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Faithfulbio has rich experience in exporting raw materials and has established stable and long-term cooperative relations with our customers. We always put product quality and service first. If you have raw material purchasing needs, please contact us. We can confirm the order with you according to your purchase quantity. We also support our first cooperation starting from samples. In addition, our fast and safe transportation also enables you to Eliminate the trouble of customs clearance.
We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
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3-7 days |
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Suitable for under 50kg. |
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7-15 days |
Suitable for more than 50kg. |
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15-60 days |
Suitable for more than 500kg. |
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